Last data update: May 06, 2024. (Total: 46732 publications since 2009)
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Query Trace: Mohr EL[original query] |
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Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses
Mohr EL , McMullan LK , Lo MK , Spengler J , Bergeron E , Albarino C , Shrivastava-Ranjan P , Cheng-Feng C , Nichol ST , Spiropoulou CF , Flint M . Antiviral Res 2015 120 40-7 Host cell kinases are important for the replication of a number of hemorrhagic fever viruses. We tested a panel of kinase inhibitors for their ability to block the replication of multiple hemorrhagic fever viruses. OSU-03012 inhibited the replication of Lassa, Ebola, Marburg and Nipah viruses, whereas BIBX 1382 dihydrochloride inhibited Lassa, Ebola and Marburg viruses. BIBX 1382 blocked both Lassa and Ebola virus glycoprotein-dependent cell entry. These compounds may be used as tools to understand conserved virus-host interactions, and implicate host cell kinases that may be targets for broad spectrum therapeutic intervention. |
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